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Further portrayals and references to masturbation have occurred throughout literature, and the practice itself has even contributed to the production of literature among certain writers, such as Wolfe, Balzac, Flaubert and John Cheever.[171]Perhaps the most famous fictional depiction of masturbation occurs in the «Nausicaa» episode of Ulysses by James Joyce. Here, the novel’s protagonist Bloom brings himself to covert climax during a public fireworks display after being aroused by a young female’s exhibitionism. Religions vary broadly in their views of masturbation, from considering it completely impermissible (for example in Catholicism, most forms of Islam, and some sects of Judaism)[165] to encouraging and refining it (as, for example, in some Neotantra and Taoist sexual practices). A male whose penis is bluntly traumatized during intercourse or masturbation may, rarely, sustain a penile fracture[106][112][113] or develop Peyronie’s disease.[114] In these cases, any energetic manipulation of the penis can cause discomfort or further damage. Like other steroid hormones, testosterone is derived from cholesterol (Figure 1).[156] The first step in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), a mitochondrial cytochrome P450 oxidase with the loss of six carbon atoms to give pregnenolone.

• Although testosterone levels normally evolve during puberty, deficient testosterone production after a β-hCG stimulation test becomes evident and hypergonadotropic hypogonadism with severe testicular atrophy and azoospermia in biopsied testes is clearly manifested in adulthood15,16).
• Another study examined the effects of high versus low monetary incentives on pain tolerance among females and males, anticipating that high external incentives would produce stronger effects among females, because males possess higher endogenous motivation to tolerate pain.257 However, the incentive manipulation had no effect on pain tolerance for females or males.
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Here, we report a 4.2-year-old SRY-negative 46,XX boy with complete sex reversal caused by SOX9 duplication for the first time in Korea. He showed normal external and internal male genitalia except for small testes. Fluorescence in situ hybridization and polymerase chain reaction (PCR) analyses failed to detect the presence of SRY, and SOX9 intragenic mutation was not identified by direct sequencing analysis.

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As technology evolves, so too do the capabilities of these AI entities, offering a glimpse into the future of human-AI relationships. Additional research has attempted to manipulate other gender-related variables. Fillingim et al119 provided instructions designed to manipulate females’ and males’ perceived ability to tolerate ischemic pain, hypothesizing that enhancing perceived ability would produce greater effects in females, because males report higher perceived ability to tolerate pain at baseline. Surprisingly, the group with the highest pain tolerance was males who had been informed that females tolerate the procedure better. In contrast, Robinson and colleagues333 found that sex differences in cold pain tolerance were nonsignificant when participants were given gender-specific expectations for pain tolerance.

Moreover, the inconsistency of findings from brain imaging studies can be attributed not only to the vast methodological differences across studies but also to their small sample sizes. Sex differences in endogenous pain modulation have received more limited attention, but the available evidence suggests that males and females may differ in this regard as well, though the direction and magnitude of the effects are quite variable. The mechanisms and practical importance of these sex differences merit further investigation in future studies.

Next, we will review recent findings regarding sex differences in experimental pain sensitivity. Many studies have investigated the prevalence of musculoskeletal pain in men and women, with some assessing chronic musculoskeletal pain irrespective of the site, whereas others have been site specific. In a previous review, Rollman and Lautenbacher341 concluded that women have greater frequency of musculoskeletal pain than men.

Today’s Kinsey Institute is a dynamic interdisciplinary research center and archival collection, world-renowned for research, historical preservation, and education programs exploring sex, sexuality, relationships, and well-being. We welcome you to join us in the discovery of the unknown as we continue to advance knowledge and change the world for the better. For more than 75 years, the Kinsey Institute at Indiana University has been the trusted source for scientific knowledge and research on critical issues in sexuality, gender, and reproduction.